Pycnogenol Benefits Endometriosis

Research on Pycnogenol for endometriosis suggests the pine bark extract may safely and naturally help to reduce symptoms. Endometriosis is a women’s health issue that occurs when uterine tissues grow abnormally, migrating to other areas of the reproductive system, digestive system, urinary tract or elsewhere.

The condition is linked to discomfort, pain and menstruation difficulties that may be worse than normal. Endometriosis may also cause reproductive complications and difficulties in conceiving.

Research Suggests Pycnogenol Benefits Endometriosis

Hormone drug therapy with Gonadotropin Releasing Hormone Agonists (GnRHa) are a standard treatment for alleviating endometriosis discomfort. For those seeking a more natural means of addressing endometriosis pain, Pycnogenol appears to have some promise:

One 2007 study, published in the Journal of Reproductive Medicine, measured Pycnogenol’s efficacy in easing endometriosis pain compared against more conventional treatment methods. 58 women were split into groups who took either Pycnogenol 60 mg (32 patients were in this group) or standard GnRHA therapy (26 patients) for 48 weeks, and were tested at weeks 4, 12, 24 and 48 to evaluate their symptom scores.

  • At the study’s conclusion, researchers reported that Pycnogenol “slowly but steadily” reduced endometriosis discomfort and symptom scores, suggesting that the pine bark extract “is a therapeutic alternative to GnRHA in the treatment of endometriosis.”

While researchers noted that Gn-RHa appeared to be significantly more efficient than PYC at helping with endometriosis, the standard drug therapy was also found to have a “clear rebound effect” — meaning that after treatment, the symptoms came back.

Researchers also pointed out that neither PYC French Maritime Pine Bark Extract or Gn-RHa seemed to influence the subjects’ estrogen levels or change their menstrual cycles in any way. These findings appear to contrast with another study of similar size that found some degree of success in administering 30 mg Pycnogenol for PMS discomfort.

PYC’s potential in easing endometriosis, as illustrated in the above study, appears to support the extract’s reputation for being a safe, effective and natural means of assisting with various aspects of women’s health and wellness.


Kohama T, et al. Effect of French maritime pine bark extract on endometriosis as compared with Leuprorelin acetate. J Rep Med, in print, 2007.

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