Pycnogenol Nitric Oxide Benefits

Pycnogenol nitric oxide benefits are a result of its interaction with endothelial cells throughout the body’s circulatory system. The endothelium is a layer of cells that line blood vessels throughout the body, helping to regulate their function, and in turn, overall blood flow.

Pycnogenol triggers the endothelium’s production of an important metabolic signaling compound called nitric oxide (NO). Among its many signaling duties in the human body, NO signals blood vessels to relax and open up – creating the perfect climate for robust, free-flowing circulation. PYC is considered a potent nitric oxide booster.

In addition to boosting circulation, healthy nitric oxide production is further associated with overall cardiovascular health, peak cognitive performance and healthy immune system function.

Pycnogenol’s ability to boost nitric oxide may be its key mechanism for supporting circulation.

  • In one animal study, Researchers found that the more Pycnogenol was added to aortic rings (part of the primary blood vessels) in tissue baths, the greater the relaxation of aortic rings was observed. Researchers concluded that Pycnogenol caused endothelium-dependent vasorelaxation, and further suggested that Pycnogenol’s influence on vascular relaxation may be a result of its ability to stimulate proper NO production.*

Nitric Oxide is a Key Compound for Vitality

When Pycnogenol helps to regulate nitric oxide production, it’s supporting a molecular celebrity. Nitric oxide (NO) was named “Molecule of the Year” by Science journal in 1992. Six years later,a team of scientists received the Nobel Prize for Physiology and Medicine for their work in discovering how the many nitric oxide effects may enhance health.

Nitric oxide attracts significant attention for its wellness potential because it works to:

  • Mediate blood pressure and prevent blood cell clumping (platelet aggregation), making it a crucial component in optimal circulation.
  • Triggers vasodilation, promotes blood vessel repair and new blood vessel growth, and protects the heart from injury and cell damage.
  • Optimizes cardiovascular system performance for enhanced efficiency in the body’s use of oxygen.
  • Neutralizes harmful free radicals in arterial walls, lending further circulatory support.
  • Plays a role in promoting neurotransmitter signaling between nerve cells in the brain.
  • Helps to balance immune and inflammatory responses.

Further emphasizing NO’s importance in health, researchers have observed that humans with atherosclerosis, diabetes or hypertension often show impaired NO pathways, and that decreased bioavailability of NO is associated with arterial stiffness, hypertension, atherosclerosis, and cardiovascular disease (CVD).


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