Study: Pycnogenol 150 mg for Cognitive Performance

One 2009 study published in Journal of Alzheimer’s Disease investigated how Pycnogenol might help with age-related cognitive decline. Both dementia and Alzheimer’s have been linked to free radical damage and oxidative stress in the brain. PYC’s high antioxidant activity and ability to cross the blood-brain barrier were suggested

In the study, 101 subjects between the ages of 60 and 85 took 150 mg Pycnogenol or placebo daily for three month. Throughout the study, the subjects were tested for multiple aspects of cognitive performance, including focus, memory and psychomotor skills.

  • At study’s end, researchers reported that Pycnogenol appeared to significantly help with cognition, especially in the Quality of Working Memory index. The researchers also found that markers of oxidative stress known as F2-isoprostanes appeared to be reduced in the PYC group. Lower oxidative stress markers may suggest higher antioxidant activity in the blood and the brain.

Pycnogenol-Cognitive-Performance


Bennett S, Grant MM, Aldred S. Oxidative stress in vascular dementia and Alzheimer’s disease: a common pathology. J Alzheimers Dis. 2009;17(2):245-57. doi: 10.3233/JAD-2009-1041.
Ryan, J, et al. An examination of the effects of the antioxidant Pycnogenol on cognitive performance, serup lipid profile, endocrinological and oxidative stree biomarkers in an elderly population. Journ of Pyschopharmacology, 22(5) (2008)
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